Supplementary material for: Regional specificity of the cingulate cortex thickness association with the intensity of psilocybin experience: a replication study
Zenodo (CERN European Organization for Nuclear Research) December 13, 2025 Gregus, David, Hlinka, Jaroslav, Tylš, Filip et al.
Cingulate cortex thickness patterns, not just a single region, predict how intensely people experience altered states of consciousness under psilocybin. In 25 healthy adults given psilocybin or placebo in a double-blind crossover design, an anterior-to-posterior gradient of cingulate thickness strongly correlated with psychedelic experience intensity. The previously reported link between rostral anterior cingulate thickness and emotional response showed a similar effect size but was not statistically significant, likely due to the smaller sample. The spatial organization across the cingulate cortex, rather than thickness in one area, appears to be a neuroanatomical marker of variability in psychedelic response.