Triple Network Model Dynamically Revisited: Lower Salience Network State Switching in Pre-psychosis
Frontiers in Physiology February 11, 2020 Thomas A. W. Bolton, Diana Wotruba, Roman Buechler et al. 83 citations
Altered coordination between the default mode, central executive, and salience networks is linked to schizophrenia, but its role in earlier at-risk stages is unclear. Using dynamic functional connectivity and co-activation pattern analysis of resting-state fMRI, this study examined right anterior insula interactions in 19 individuals with subthreshold delusions and hallucinations (UHR), 28 with basic symptoms of self-experienced subclinical disturbances (BS), and 29 healthy controls. The right anterior insula governs transitions from the central executive to default mode network, which become dysfunctional before psychosis onset, especially when attenuated psychotic symptoms emerge.