Ketamine in the treatment of bipolar depression
Brazilian Journal of Health Review January 28, 2026 Juliana Chies Galvan, Marina Chies Galvan, Rafael Moreno Ferro de Araújo
Ketamine appears to be an alternative treatment for bipolar depression when first- and second-line medications are not effective, according to a review of six clinical trials published between 2010 and 2021. Bipolar depression is the most common mood state in bipolar disorder, yet few studies have focused on its treatment. The review examined evidence on ketamine used either as an adjuvant or as monotherapy. The results suggest ketamine may be effective, but future studies are needed to confirm this.