Effect of Esketamine on Postoperative Delirium and Inflammatory Response in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting: A Randomized Controlled Study.
Journal of cardiothoracic and vascular anesthesia April 10, 2025 Liang-Yu Ju, Guo-Qiang Liu, Li Yuan et al. 4 citations
In patients undergoing off-pump coronary artery bypass grafting, continuous intravenous infusion of esketamine during surgery reduced the incidence of postoperative delirium within the first seven days by about half compared with a placebo infusion of saline. Esketamine also lowered levels of the inflammatory markers interleukin-6 at 12 and 72 hours after surgery and C-reactive protein at 72 hours. The findings suggest that esketamine can decrease postoperative delirium and short-term inflammatory responses in this patient population.