Psychopathology and Psychophysiology of Minimal LSD-25 Dosage
A M A Archives of Neurology & Psychiatry February 1, 1958 Theodore Greiner 47 citations
After 14 years of research, the full range of human responses to lysergic acid diethylamide (LSD-25) remains incompletely described. Most attention has focused on dramatic schizophrenic-like symptoms produced by doses of 40μg to 100μg. The threshold for activity is generally accepted as 20μg, but the effects of smaller doses are uncertain due to perfunctory administration. A controversy exists over whether LSD symptoms mimic schizophrenia or represent a toxic organic psychosis. This preliminary note reports that understanding the complete dosage-response relationship could help resolve this debate, though early stages of toxic psychosis have rarely been described in psychopathological terms, while a firmer basis exists for comparison with schizophrenic processes.