Intravenous Ketamine Treatment for Depression: One-year Retrospective Study from a Tertiary Care Psychiatry Center from India.
Indian journal of psychological medicine April 29, 2025 Ekta Yadav, Bheemsain Tekkalaki, Kavita P Gadadavar et al. 2 citations
Ketamine infusion therapy, when used alongside other treatments, rapidly reduces depression symptoms in patients with major depressive disorder. In a retrospective chart review of 28 patients at a tertiary care hospital, scores on the Hamilton Depression Rating Scale (HAMD) dropped significantly after an average of 4.6 infusions. More than half of patients (53.6%) showed a therapeutic response—a 50% or greater decrease in HAMD scores—and 39.3% achieved remission, defined as a HAMD score below 7. Suicidal ideation substantially decreased in 71.4% of patients. The findings indicate that ketamine infusion therapy is a safe and effective rapidly acting adjunct treatment for depression.