Electrochemistry and analytical determination of lysergic acid diethylamide (LSD) via adsorptive stripping voltammetry
Talanta July 22, 2014 Daniele Merli, Daniele Zamboni, Stefano Protti et al. 36 citations
A simple and accurate method for measuring lysergic acid diethylamide (LSD) in biological samples uses adsorptive stripping voltammetry in DMF/tetrabutylammonium perchlorate. The method detects LSD at very low concentrations, with a linear range of 1-90 ng L(-1) for 50-second deposition times, a limit of detection of 1.4 ng L(-1), and a limit of quantification of 4.3 ng L(-1). It can be applied to biological samples after a simple extraction with 1-chlorobutane, enabling routine analysis of LSD, which is otherwise difficult to detect due to its low active dose.