Identification of 1-Butyl-Lysergic Acid Diethylamide (1B-LSD) in Seized Blotter Paper Using an Integrated Workflow of Analytical Techniques and Chemo-Informatics
Molecules February 7, 2020 Emmanouil Tsochatzis, Joao Alberto Lopes, Fabiano Reniero et al. 22 citations
A single blotter paper seized by Swedish customs was analyzed using a combination of advanced analytical techniques and chemo-informatics tools, leading to the identification of a novel lysergic acid diethylamide (LSD) derivative, 1-butyl-lysergic acid diethylamide (1B-LSD). This substance, closely related to 1-propionyl-lysergic acid diethylamide (1P-LSD), had recently appeared on the drug street market. The identification was achieved by integrating gas chromatography–mass spectrometry, liquid chromatography–high-resolution tandem mass spectrometry, Orbitrap-MS, and one- and two-dimensional nuclear magnetic resonance spectroscopy, with all data managed and evaluated through a chemo-informatics platform. The work demonstrates a workflow for identifying new psychoactive substances when sample quantity is limited or the matrix is complex.