Comparison of the discriminative stimulus properties of Δ9-THC and psilocybin in rats
Pharmacology Biochemistry and Behavior September 1, 1975 Isaac Greenberg, D. M. Kuhn, James B. Appel 17 citations
Male albino rats learned to press either a left or right lever depending on which drug they had received 30 minutes earlier. One group discriminated between 1.9 mg/kg of delta9-THC and a vehicle control; another group discriminated between 1.0 mg/kg of delta9-THC and 1.0 mg/kg of psilocybin. The results confirmed that delta9-THC can serve as a discriminative stimulus controlling behavior. Because rats reliably chose different levers after delta9-THC versus psilocybin, the two drugs likely produce distinct internal states in rats.