LSD: Autoradiographic Study on the Placental Transfer and Tissue Distribution in Mice
Science June 13, 1969 Juhana E. Idänpään-heikkilä, Joseph C. Schoolar 32 citations
Intravenously administered 14C-lysergic acid diethylamide rapidly moved from blood into tissues within minutes. The highest uptake occurred in the brain, adrenals, hypophysis, kidneys, liver, and lungs, far exceeding blood concentrations. Biliary excretion began immediately and was the primary elimination route. During early pregnancy, 2.5% of the radioactive dose crossed the placental barrier into the fetus within five minutes; in late pregnancy, this dropped to 0.5%. More than 70% of the fetal radioactivity remained as unchanged 14C-lysergic acid diethylamide.