Acute effects of lysergic acid diethylamide (LSD) on resting brain function
Swiss Medical Weekly September 30, 2019 Felix Mller, Stefan Borgwardt 10 citations
LSD produces extensive alterations in functional brain connectivity, particularly increasing connectivity within the thalamocortical system. These changes align with models suggesting hallucinogenic drugs inhibit cerebral filtering of external and internal data. Recent neuroimaging studies in the UK and Switzerland using fMRI have revived research into LSD's neuronal effects, which were unclear despite decades of earlier psychiatric investigation into its potential for treating depression, anxiety, addiction, and personality disorders. However, these studies face limitations, including potential biases in neuroimaging measurements.