Synthesis of deuterium labeled standards of 5‐methoxy‐N,N‐dimethyltryptamine (5‐Meo‐DMT)
Journal of Labelled Compounds and Radiopharmaceuticals August 14, 2006 Ya-Zhu Xu, Chinpiao Chen 14 citations
A deuterium-labeled version of the psychedelic compound N,N-dimethyltryptamine (DMT) was synthesized. Starting from a commercially available nitroaromatic compound, the 5-methoxy group was labeled with three deuterium atoms using deuterated iodomethane. The synthesis followed the Batcho-Leimgruber indole synthesis, then introduced the side chain via oxalyl chloride and dimethylamine, and finally reduced the amide with lithium aluminum hydride to give 5-[2H3]-methoxy-N,N-dimethyltryptamine.