Interaction between narcotic antagonist (naloxone) and lysergic acid diethylamide (LSD) in the rat
Psychopharmacology January 1, 1977 Allen P. Fertziger, Roland Fischer 12 citations
In rats, lysergic acid diethylamide (LSD) produces a two-phase response: a brief period of excitement lasting up to 8 minutes, followed by a prolonged catalepsy lasting from 8 minutes to 1 hour. A single injection of naloxone given 30 minutes after LSD administration blocks the cataleptic phase. However, when naloxone is given before LSD, it shortens the excitable phase and makes the catalepsy stronger.