Acute effects of ayahuasca in a juvenile non-human primate model of depression
Brazilian Journal of Psychiatry November 21, 2018 Flávia S. Da Silva, Erick Allan Dos Santos Silva, Geovan Menezes de Sousa et al. 46 citations
In a juvenile marmoset model of depression, a single dose of ayahuasca reversed stress-induced hypocortisolemia within 24 hours, reduced stereotypic scratching in males, increased feeding in males, and restored body weight in both sexes, with behavioral effects lasting up to 14 days. Saline vehicle did not produce these effects. The findings suggest ayahuasca may have rapid and sustained antidepressant properties, supporting further research into psychedelics for early-onset depression.