Quantitative Analysis of Substituted N,N-Dimethyl-tryptamines in the Presence of Natural Type XII Alkaloids
Natural Product Communications October 1, 2012 Bojidarka Ivanova, Michael Spiteller 2 citations
A validated analytical protocol using electronic absorption spectroscopy achieves a limit of detection of 7.2 × 10⁻⁷ mol/L and a limit of quantification of 24 × 10⁻⁷ mol/L for mixtures of hallucinogens including N,N-dimethyltryptamine (DMT) and its derivatives in the presence of β-carbolines. Additional protocols using HPLC, ESI-MS, MS/MS, MALDI-MS, and Raman spectroscopy are partially validated. The known synergistic effect that increases psychoactive properties and reported acute poisoning cases from these compounds underscore the need for such precise analytical methods, which are relevant to criminal forensic analysis.