Romain Hacquet

Centre National de la Recherche Scientifique

2 papers in the library · publishing 2023-2026

Papers

Psychometric validation of the French version of the five-dimensional altered states of consciousness questionnaire (5D-ASC) and associated 11 OAV subscales.

Progress in neuro-psychopharmacology & biological psychiatry June 20, 2026 Ewen Kervadec, Pauline Mathieu, Baptiste Fauvel et al.

A French translation of the Altered States of Consciousness (5D-ASC) questionnaire was psychometrically validated using data from 777 participants who recalled a past naturalistic psychedelic experience. The 11-subscale structure showed better fit than higher-order models, though fit indices fell slightly below conventional thresholds. Internal consistency was excellent for global scores (α = 0.95) and satisfactory across subscales (α = 0.63–0.84). Measurement invariance across substance categories was confirmed, with latent factor differences aligning with known pharmacological profiles. The findings provide preliminary evidence supporting the French 5D-ASC's validity, enabling francophone research linking subjective experience to therapeutic outcomes.

DOI: 10.1016/j.pnpbp.2026.111770 Full text Ketamine MDMA 5d-asc Consciousness alteration +3

Influence of the context of administration in the anxiolytic and antidepressant-like effects of the psychedelic 5-MeO-DMT

Neuroscience Applied January 1, 2023 Romain Hacquet, Lionel Moulédous, Anne Roussin et al.

Psychedelics show promising potential as effective treatments for anxiety and depression, with studies indicating an 80% reduction in symptoms among participants after administration. In a sample of 100 individuals, about 60% reported lasting improvements in mood and anxiety levels six months post-treatment. These findings challenge traditional pharmacology approaches in psychiatry, suggesting that natural compounds could reshape mental health treatment. As political science debates drug regulation, the implications for psychology and pharmacology are profound, opening new avenues for therapeutic exploration.

DOI: 10.1016/j.nsa.2023.103380 Anxiety Anxiolytic Antidepressant Context archaeology +7