Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
July 16, 2025
Amel Bouloufa, Sarah Delcourte, Renaud Rovera et al.
12 citations
Acute administration of LSD produces fast antidepressant- and anxiolytic-like effects in rats, along with hallucinatory-like effects and suppression of serotonin neuron activity. These effects are blocked by a selective 5-HT2B receptor antagonist, indicating they depend on activation of 5-HT2B receptors. Depletion of serotonin also prevents LSD's effects in the forced swim test and head-twitch response. In mice, LSD fails to produce antidepressant- or anxiolytic-like effects, and its hallucinogenic-like effect is not altered by 5-HT2B receptor blockade. The findings suggest LSD acts as a rapid-onset antidepressant in rats but not in mice, through mechanisms involving 5-HT2B receptor activation.
Neuroscience & Biobehavioral Reviews
October 10, 2025
Amel Bouloufa, Sarah Delcourte, Thomas Delannay et al.
3 citations
Major depressive disorder affects over 350 million people worldwide, and about 30% of those with the condition have treatment-resistant depression that does not respond adequately to standard antidepressants targeting serotonin, noradrenaline, or dopamine. Psychedelic medicines such as lysergic acid diethylamide (LSD) are being investigated as potential treatments because they affect both serotonergic and glutamatergic systems and may induce rapid, long-lasting antidepressant effects by facilitating neuroplasticity and adjusting neural communication even after the drug is cleared. Ongoing clinical trials are testing LSD's efficacy and safety in treatment-resistant depression while addressing placebo design and risk minimization.
Neuroscience Applied
January 1, 2023
Romain Hacquet, Lionel Moulédous, Anne Roussin et al.
Psychedelics show promising potential as effective treatments for anxiety and depression, with studies indicating an 80% reduction in symptoms among participants after administration. In a sample of 100 individuals, about 60% reported lasting improvements in mood and anxiety levels six months post-treatment. These findings challenge traditional pharmacology approaches in psychiatry, suggesting that natural compounds could reshape mental health treatment. As political science debates drug regulation, the implications for psychology and pharmacology are profound, opening new avenues for therapeutic exploration.