Among 169 gay and bisexual men at New York City dance clubs, about one-third reported using MDMA at least monthly. MDMA use was strongly and significantly linked to recent unprotected anal intercourse, and this link held even after accounting for age, ethnicity, and other drug use including alcohol. The authors suggest MDMA abuse and its association with high-risk sexual behaviors represent important but unexplored public health problems for some gay and bisexual men.
A guided psychedelic experience with psilocybin may treat refractory depression by inducing a mystical experience, rather than through a simple biological drug effect. The text suggests that the therapeutic benefit could stem from the profound, transformative nature of the experience, as conceptualized by William James.