Diffusion Tensor Imaging in MDMA Users and Controls: Association with Decision Making
The American Journal of Drug and Alcohol Abuse January 1, 2007 F. Gerard Moeller, Joel L. Steinberg, Scott D. Lane et al. 39 citations
MDMA users showed reduced longitudinal diffusivity in the rostral body of the corpus callosum, indicating possible microstructural changes, while no differences were found in other diffusivity measures. MDMA users also reported higher impulsivity on the Barratt Impulsiveness Scale and made more disadvantageous choices on the Iowa Gambling Task. A positive correlation emerged between longitudinal diffusivity in the rostral corpus callosum and advantageous decision-making, suggesting a link between white matter integrity and cognitive performance. Further research is needed to understand the causes of these associations.