Simultaneous Analysis of Amphetamine, Methamphetamine, and 3,4-Methylenedioxymethamphetamine (MDMA) in Urine Samples by Solid-Phase Extraction, Derivatization, and Gas Chromatography/Mass Spectrometry
Journal of Forensic Sciences September 1, 1991 Ber K. Gan, Daniel Baugh, Rh Liu et al. 54 citations
A solid-phase extraction method using Bond Elute Certify™ cartridges extracts amphetamine, methamphetamine, and MDMA from urine. The extract is derivatized with trichloroacetic anhydride and analyzed by gas chromatography/mass spectrometry with selected ion monitoring. Recovery exceeds 65% with less than 5% coefficient of variation. The lowest detectable concentration is about 50 ng/mL using a 2 mL sample. Within the 250 to 4000 ng/mL range, a second-order polynomial model yields a near-perfect fit.