Synthesis of a Tricyclic Mescaline Analogue by Catalytic C−H Bond Activation
Organic Letters March 22, 2003 Kateri A. Ahrendt, Robert G. Bergman, Jonathan A. Ellman 99 citations
A tetrahydrobis(benzofuran) mescaline analogue was synthesized in six steps with a 38% overall yield starting from (4'-O-methyl)methyl gallate. The key step involved a tandem cyclization reaction using directed C–H activation followed by olefin insertion. This approach demonstrates an efficient route to a tricyclic compound related to mescaline.