Determination of amphetamine, methamphetamine, 3,4‐methylenedioxyamphetamine, 3,4‐methylenedioxyethylamphetamine, and 3,4‐methylenedioxymethamphetamine in urine by online solid‐phase extraction and ion‐pairing liquid chromatography with detection by electrospray tandem mass spectrometry
Rapid Communications in Mass Spectrometry February 11, 2005 Ti‐yu Wu, Ming‐ren Fuh 43 citations
A fully automated method using online solid-phase extraction and ion-pairing liquid chromatography with electrospray tandem mass spectrometry was developed to measure amphetamine, methamphetamine, MDA, MDEA, and MDMA in urine. Recoveries ranged from 85 to 101%. Linear ranges were 10–500 ng/mL for amphetamine and methamphetamine, and dual linear ranges of 5–100 and 100–500 ng/mL for MDA, MDMA, and MDEA. Detection limits were 1–3 ng/mL. Testing on urine samples from drug users showed good agreement with an established GC/MS method.