Electroencephalographic studies on the development of tolerance and cross tolerance to mescaline in the rat
Psychopharmacology January 1, 1975 Brenda K. Colasanti, Naim Khazan 14 citations
In rats with permanent electrodes, mescaline initially caused immediate EEG desynchronization and behavioral arousal lasting 2-3 hours, after which slow wave sleep and REM sleep reappeared. With continued administration every 6 hours, partial tolerance developed, shown by gradually shorter latencies to sleep onset. Rats tolerant to mescaline were cross-tolerant to LSD and DET but not to amphetamine, even though amphetamine produces similar arousal and EEG effects. These findings support the usefulness of EEG as a quantitative measure of central nervous system function and align with behavioral studies of tolerance and cross-tolerance among hallucinogens.