Purdue University West Lafayette
2 papers in the library · 14 citations · publishing 1986-2025
Journal of Natural Products July 1, 1986 W.-w. Ma, Xiaomo Jiang, R. Graham Cooks et al. 10 citations
Mescaline and related alkaloids were identified in eight additional cactus species using thin-layer chromatography (TLC) and tandem mass spectrometry (MS/MS). The work extends the known distribution of these compounds across the Cactaceae family.
Angewandte Chemie International Edition June 17, 2025 Ahram Kim, Nicolás M. Morato, Prabir Saha et al. 4 citations
The enzyme PsiK, which selectively phosphorylates psilocin during psilocybin biosynthesis in Psilocybe cubensis, can also phosphorylate a wide range of substituted phenols and benzenediols beyond its natural substrate. This expands the scope of biocatalytic phosphorylation for synthetic chemistry. Active site mutations further broaden substrate scope and improve site-selectivity, with engineering expedited by DESI-MS screening that analyzed 2688 reactions in 40 minutes. Gram-scale phosphorylation of a representative substrate achieved a turnover number over 10,000. These results highlight PsiK's utility for selective phosphorylation under mild conditions.