Methylenedioxyamphetamine. Clinical description of overdose, death, and review of pharmacology
Archives of Internal Medicine October 1, 1981 David Simpson 55 citations
Methylenedioxyamphetamine, a street drug structurally similar to mescaline and amphetamine, can cause severe toxicity beyond hallucinations. A patient exhibited sympathomimetic effects, coma, seizures, hyperreflexia, and hyperthermia. Despite initial stabilization, uncontrollable hyperthermia, hematologic abnormalities, and coma led to death. Hyperthermia involves both central and peripheral mechanisms, so phentolamine (Regitine) mesylate may be the preferred treatment. The drug is not merely a mild hallucinogen.