Effect of liner properties on the analysis of lysergic acid diethylamide ( LSD ) analogs
Journal of Forensic Sciences September 21, 2025 Sarah A. Shuda 1 citation
LSD and related compounds are often present at low concentrations on forensic evidence, requiring sensitive detection methods. The inlet liner of a gas chromatograph—a consumable component that vaporizes samples—can affect how well these compounds are detected. Testing twelve different liners with a mixture of eight LSD-related compounds showed that liners containing packing material (like glass wool) produced significantly larger peak areas than unpacked liners. Liner geometry had a minor effect, only mattering with one deactivation type when glass wool was absent. Base deactivation improved peak area over standard and Topaz deactivation in straight packed liners.