Lysergic acid diethylamide pretreatment prolongs brain-stimulation induced neural activity changes
bioRxiv (Cold Spring Harbor Laboratory) December 19, 2025 Lucas L. Dwiel, Mackenzi L. Prina, Elise M. Bragg et al.
Pretreating rats with LSD before electrically stimulating the medial prefrontal cortex produces larger and longer-lasting changes in brain activity than stimulation alone. The combination activates the mTOR signaling pathway and alters perineuronal net integrity. Brain activity during stimulation does not predict the persistent brain state afterward. These findings support developing psychedelic-assisted brain stimulation to increase durability of stimulation effects, potentially reducing relapse rates in non-invasive stimulation treatments.