MDMA-assisted therapy for major depressive disorder: A seven-month follow-up proof of principle trial
Journal of Psychiatric Research November 27, 2025 Tor-Morten Kvam, Ivar W Goksøyr, Joanna Róg et al. 3 citations
In a small long-term follow-up of twelve people with major depressive disorder, MDMA-assisted therapy—two MDMA dosing sessions combined with nine psychotherapy sessions—led to sustained reductions in depression severity and disability seven months after baseline. Depression scores on the Montgomery-Asberg Depression Rating Scale and disability scores on the Sheehan Disability Scale remained significantly lower than before treatment, with no significant changes from the immediate post-treatment visit. Suicidal ideation did not exceed pre-study levels. The results suggest lasting treatment effects and safety, though the authors call for larger controlled trials to confirm these preliminary findings.