Preliminary effects of ayahuasca on mental and physical health: A systematic review of prospective studies
Progress in Neuro-Psychopharmacology and Biological Psychiatry February 8, 2026 Michael J. Haupt, Savannah Pointe, Kevin F. Boehnke et al.
Ayahuasca, a psychedelic plant brew with centuries of traditional use in Central and South America, has drawn increased drug tourism and scientific interest for potential health benefits. A systematic review of 18 prospective studies found long-term changes in wellbeing, depression, psychiatric symptoms, substance misuse, cognitive flexibility, personality, and prosocial behavior among mostly unselected volunteers at retreat centers. While population-level mental health improvements were noted, some participants experienced persisting psychiatric complications. No prospective studies examined physical health conditions, though one reported decreased physical pain and another lasting neurometabolic changes in the posterior cingulate cortex. Limitations include small samples, unstandardized dosages, and lack of control groups.