Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe
Science August 16, 1968 George K. Aghajanian, Warren E. Foote, Michael Sheard 406 citations
Injections of d-lysergic acid diethylamide (LSD) into the midbrain cause a reversible halt in the spontaneous firing of neurons that contain serotonin. The dose needed is at or below the level that produces noticeable behavioral changes. This inhibition of serotonin-containing neurons may explain the drug's effect of reducing serotonin metabolism.