Interactions between lysergic acid diethylamide and dopamine-sensitive adenylate cyclase systems in rat brain
Brain Research August 1, 1975 Kern von Hungen, Sidney Roberts, Diane F. Hill 70 citations
D-lysergic acid diethylamide (D-LSD) and other serotonin antagonists block the activation of adenylate cyclase by norepinephrine or dopamine in cell-free preparations from rat brain. In the corpus striatum, D-LSD not only blocks dopamine's effect but also stimulates adenylate cyclase activity on its own, acting as an agonist at dopamine and serotonin receptors. This activation is blocked by dopamine-blocking agents like haloperidol and by serotonin-blocking agents, but not by propranolol. The findings suggest D-LSD can both activate and block dopamine, norepinephrine, and serotonin receptors in the brain.