Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat
European Journal of Pharmacology October 1, 1985 Mark D. Tricklebank, Christian Forler, Derek N. Middlemiss et al. 141 citations
The 5-HT1A receptor subtype mediates forepaw treading behavior in rats given the serotonin agonist 5-MeODMT. In intact rats, the 5-HT2 antagonist ketanserin blocked forepaw treading only at high doses that also blocked dopamine receptors, suggesting its effect was not via 5-HT2 receptors. In rats depleted of monoamines with reserpine, neither ketanserin, haloperidol, nor beta-adrenoceptor antagonists altered forepaw treading or flat body posture, ruling out key roles for 5-HT2, dopamine, and beta receptors. Pindolol and spiperone, which interact with 5-HT1A sites, stereoselectively antagonized forepaw treading in both conditions, supporting mediation by 5-HT1A receptors. Flat body posture antagonism by pindolol occurred only in non-reserpinised rats, leaving its mechanism unclear.