Psychoactive substances as a last resort—a qualitative study of self-treatment of migraine and cluster headaches
Harm Reduction Journal September 4, 2017 Martin Andersson, Mari Persson, Anette Kjellgren 93 citations
People with treatment-resistant cluster headache and migraine often turn to online forums to discuss alternative pharmacological treatments, including illicit psychoactive substances. A qualitative thematic analysis of discussions on three forums found that patients are in a desperate and vulnerable situation, viewing such substances as a last resort. Psilocybin, lysergic acid diethylamide, and related psychedelic tryptamines were reportedly effective for both preventing and treating attacks, while cannabis results were more unpredictable. Users showed little interest in psychoactive effects, often using sub-psychoactive doses to avoid them. No severe adverse events were reported, but desperation sometimes led to risky behavior in obtaining and testing treatments.