Impact of Medical Comorbidities on Ketamine and Esketamine Treatment Effectiveness for Posttraumatic Stress Disorder and Depression: A Clinical Outcomes Analysis from the VA San Diego Healthcare System.
CNS drugs June 1, 2025 Sijia Zhang, Houtan Afshar, Peter J Colvonen et al. 1 citation
Repeated ketamine or esketamine sessions significantly reduced depression and PTSD symptoms in veterans. However, those who also had traumatic brain injury (TBI) and severe obstructive sleep apnea (OSA) did not show improvement in depression, suggesting that these comorbidities may require alternative or pre-treatment before starting ketamine or esketamine therapy.