Bringing MDMA-assisted therapy for PTSD to traditional healthcare systems: tending to set and setting.
Frontiers in psychiatry January 1, 2025 Dimitri Perivoliotis, Kayla Knopp, Shannon Remick et al. 2 citations
Set and setting—the mindset a person brings to therapy and the environment in which it occurs—are foundational to MDMA-assisted therapy for PTSD and critically influence its efficacy. Drawing on experience conducting clinical trials in the Veterans Health Administration, this article describes advantages and challenges of implementing this intervention in large healthcare systems. Specific, practical suggestions are offered for optimizing set and setting from both participant and clinician perspectives, aiming to leverage opportunities and adapt to challenges. These recommendations are intended to inform future research and potential clinical implementation efforts in traditional healthcare settings.