PM502. Effect of psilocybin on EEG brain connectivity in healthy volunteers – preliminary report
The International Journal of Neuropsychopharmacology May 27, 2016 Tomáš Páleníček, Filip Tylš, Michaela Viktorinová et al. 6 citations
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Renata Androvičová
National Institute of Mental Health
2 papers in the library · 6 citations · publishing 2016-2026
Papers
EEG microstate dynamics during psilocybin intoxication relate to acute experience and persisting psychological changes
bioRxiv (Cold Spring Harbor Laboratory) June 12, 2026 Nikola Jajcay, Čestmír Vejmola, Jakub Korčák et al.
Psilocybin accelerates the temporal dynamics of large-scale brain activity while preserving access to the normal repertoire of brain states. In a double-blind, placebo-controlled crossover study of 15 healthy volunteers, EEG microstate analysis revealed that psilocybin increased the number of global field power peaks and reduced microstate lifespan while increasing their frequency of occurrence during peak intoxication (50–100 minutes after administration), indicating faster transitions between brain states. Microstate coverage was largely unchanged except for a transient difference in the 2–20 Hz bandwidth. Individual differences in these microstate dynamics correlated with both acute subjective experience intensity and self-reported psychological changes 28 days later, suggesting EEG microstates as candidate neural markers linking acute psychedelic effects to longer-term outcomes.