Prevalence and Reasons for Microdosing Cannabis, Psilocybin, LSD, and MDMA Among U.S. Adults
American Journal of Preventive Medicine May 4, 2026 Kevin H. Yang, Nora Satybaldiyeva, Wayne Kepner et al. 1 citation
Cannabis is the most commonly microdosed substance among U.S. adults, with 9.4% (24.1 million) reporting lifetime use, followed by psilocybin (5.3%, 13.7 million), LSD (4.8%, 12.4 million), and MDMA (2.2%, 5.7 million). Cannabis is primarily microdosed for medical reasons such as pain management, whereas psilocybin, LSD, and MDMA are more often used recreationally. Lifetime microdosing is more prevalent among people with poorer mental health and those living in jurisdictions with fewer restrictions on cannabis and psychedelics. As policies continue to evolve, the prevalence of microdosing may increase, highlighting the need for ongoing surveillance.