American Journal of Preventive Medicine
June 10, 2024
Eric C. Leas, Nora Satybaldiyeva, Wayne Kepner et al.
10 citations
Use of psilocybin-containing mushrooms among U.S. adults rose from 11.4% in 2021 to 12.3% in 2022, making them the most commonly used hallucinogenic substance. This growing interest has spurred a commercial market for other mushrooms, including Amanita muscaria, which contains the psychoactive compounds muscimol and ibotenic acid.
American Journal of Preventive Medicine
May 4, 2026
Kevin H. Yang, Nora Satybaldiyeva, Wayne Kepner et al.
1 citation
Cannabis is the most commonly microdosed substance among U.S. adults, with 9.4% (24.1 million) reporting lifetime use, followed by psilocybin (5.3%, 13.7 million), LSD (4.8%, 12.4 million), and MDMA (2.2%, 5.7 million). Cannabis is primarily microdosed for medical reasons such as pain management, whereas psilocybin, LSD, and MDMA are more often used recreationally. Lifetime microdosing is more prevalent among people with poorer mental health and those living in jurisdictions with fewer restrictions on cannabis and psychedelics. As policies continue to evolve, the prevalence of microdosing may increase, highlighting the need for ongoing surveillance.