Cognitive and subjective effects of psilocybin microdosing: Results from two double-blind placebo-controlled longitudinal trials
Neuropharmacology October 17, 2025 Luisa Prochazkova, Josephine Marschall, Dominique P. Lippelt et al. 3 citations
Microdosing psilocybin truffles does not reliably enhance cognitive or emotional functioning beyond a placebo. In two randomized, double-blind, placebo-controlled trials conducted in semi-naturalistic settings, microdosing did not significantly affect behavioral or subjective measures compared to placebo. Some initial effects on social cognition, mood, and self-reported cognitive flexibility were observed but did not remain significant after correcting for multiple comparisons. Participants predominantly reported positive subjective experiences regardless of condition, though negative bodily feelings were enhanced in the active condition. Participants remained effectively blinded throughout the trials.