Ketamine and serotonergic psychedelics: An update on the mechanisms and biosignatures underlying rapid-acting antidepressant treatment
Neuropharmacology January 13, 2023 Jenessa N. Johnston, Bashkim Kadriu, Josh Allen et al. 64 citations
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Jenessa N. Johnston
National Institute of Mental Health
2 papers in the library · 89 citations · publishing 2020-2023
Papers
Ketamine Rescues Hippocampal Reelin Expression and Synaptic Markers in the Repeated-Corticosterone Chronic Stress Paradigm
Frontiers in Pharmacology September 2, 2020 Jenessa N. Johnston, Jonathan S. Thacker, Charissa Desjardins et al. 25 citations
In adult male rats exposed to repeated corticosterone (a model of depression), ketamine restored the expression of reelin, a protein implicated in depression, and both reelin and ketamine rescued synaptic levels of mTOR and its activated form p-mTOR in the hippocampus and cerebellum, which had been reduced by corticosterone. Reelin, but not ketamine, also normalized serotonin transporter clustering on peripheral lymphocytes. These results suggest ketamine modulates reelin expression and support exploring reelin itself as a potential fast-acting antidepressant.