DETERMINATION OF TRYPTAMINE ALKALOIDS AND THEIR STABILITY IN PSYCHOTROPIC MUSHROOMS
The International Journal of Neuropsychopharmacology February 1, 2025 Martin Kuchař, Klara Gotwaldova, Jan Borovička et al. 1 citation
Tryptamine concentrations in psychotropic mushrooms vary enormously, which may alter medicinal effects compared to chemically pure psilocybin. Storage conditions strongly affect alkaloid decay: the greatest degradation occurred in fresh mushrooms stored at −80°C, while the least decay was seen in dried biomass kept in the dark at room temperature. The study measured psilocybin, psilocin, baeocystin, norbaeocystin, and aeruginascin in a large sample set of mushroom genera, using freshly cultivated Psilocybe cubensis fruit bodies for stability monitoring, and analyzed mycelium and individual fruiting body parts with validated UHPLC-MS/MS.