Therapeutic potential of serotoninergic psychedelic substances in the treatment of Obsessive Compulsive Disorder
European Psychiatry June 1, 2022 Jaime Rodrigues, O. Nombora, Luiz Vicente Ribeiro 1 citation
A non-systematic review of the current evidence on serotoninergic psychoactive substances for obsessive-compulsive disorder (OCD) finds that, although research is limited to a few small studies, those conducted so far show clinically meaningful acute reductions in OCD symptoms after treatment with drugs such as psilocybin and lysergic acid diethylamide (LSD), along with possible longer-lasting benefits. Substance-assisted psychotherapy with psychedelics also shows promising results and appears suitable for OCD treatment. Studies indicate relatively good tolerability to these drugs. These early findings highlight the role of psychedelics in OCD treatment and the need for further research into efficacy, therapeutic mechanisms, and safety.