Physarum-Mediated Biofeedback Rehabilitation: A Bio-Hybrid Framework for Ibogaine-Assisted Neural Recovery
Zenodo (CERN European Organization for Nuclear Research) June 12, 2026 Saeid Ghiasi
A system is described that maps human brain activity (EEG frequency, amplitude, and phase) to the behavior of a living slime mold (Physarum polycephalum) to create a biohybrid interface for addiction recovery. The slime mold's network growth and retraction are controlled by nutrient gradients that correspond to neural signals: higher activation in addiction-related brain regions reduces food at corresponding Physarum nodes, causing network retraction. The system is presented as a structural isomorphism—not a metaphor—between neural plasticity, Physarum tube reinforcement, and ibogaine's neurorestorative mechanisms (NMDA receptor blockade, BDNF/GDNF upregulation). The document is a defensive publication establishing prior art under patent treaties, released under CC-BY 4.0.