Department of Neurobiology, University of Utah, 20 S. 2030 E., BPRB 320, Salt Lake City, UT 84112, USA. Electronic address: adam.douglass@neuro.utah.edu.
A tendency to become passive when facing overwhelming challenges is a hallmark of depression. In a zebrafish model of this phenomenon, the antidepressant ketamine promotes long-term improvements in behavioral persistence through a newly discovered mechanism.