Efficacy of N, N-dimethyltryptamine (DMT) psychedelic therapy for substance misuse: A systematic review and meta-analysis
Journal of Psychopharmacology April 12, 2026 L. M. Wallace, Andrea Bujor, Gustavo Sudre et al.
A systematic review and meta-analysis of studies from 1960 to 2024 found that the psychedelic agent DMT produced a large overall effect on reducing substance abuse (g = 0.94). Effects were larger for drug use (g = 1.35) than for alcohol use (g = 0.65). Studies that included psychotherapy showed significantly greater effects (g = 1.38) than those without (g = 0.60). However, the included studies had high risk of bias and high heterogeneity, so the findings should be considered preliminary rather than proof of established efficacy.