Comparison of the hallucinogenic indole alkaloids ibogaine and harmaline for potential immunomodulatory activity.
Pharmacology June 1, 1995 R V House, P T Thomas, H N Bhargava 12 citations
Indole alkaloids ibogaine and harmaline suppress several immune functions in a dose-dependent manner in laboratory tests. At high concentrations (10–100 μmol/L), both compounds reduced T-cell regulatory and effector activity, B-cell function, and natural killer-cell function. Macrophage function was not affected. The suppression was observed across multiple assays, suggesting a broad immunomodulatory effect at elevated doses.