Psychedelics as Transformative Therapeutics
Carolina Digital Repository May 11, 2024 Roth B.l, Gumpper R.h
Psychedelic compounds are being investigated as potential treatments for several neuropsychiatric conditions, including depression, cluster headaches, migraines, anxiety, and obsessive-compulsive disorder. This review describes the biological mechanisms underlying these therapeutic effects, focusing on the serotonin 5-HT2A receptor system, and discusses recent drug discovery efforts. It also highlights potential pitfalls in the widespread clinical use of psychedelics, emphasizing the need to understand both their pharmacology and risks.