Noribogaine effects on wakefulness and sleep
bioRxiv (Cold Spring Harbor Laboratory) July 28, 2023 Juan Pedro Castro‐nin, Diego Serantes, Paola Rodrı́guez et al. 1 citation preprint
Noribogaine, the main metabolite of the psychedelic ibogaine, promotes wakefulness and reduces slow-wave sleep while completely blocking REM sleep in rats. These sleep-wake alterations mirror those caused by ibogaine itself, suggesting that noribogaine is responsible for the sleep-suppressing effects previously attributed to ibogaine. The findings point to serotonin reuptake inhibition as a likely mechanism underlying the wake-promoting and REM sleep-suppressing actions of both compounds.