Effect of Esketamine Compared with Sufentanil Combined with Propofol in Patients Undergoing First Trimester Surgical Abortion: A Randomized, Double-Blinded Clinical Trial.
Drug design, development and therapy January 1, 2025 Yingchao Guan, Haochen Wang, Xiaojing Cong et al.
Esketamine anesthesia during first-trimester surgical abortion maintains more stable blood pressure and heart rate compared with sufentanil, and keeps end-tidal carbon dioxide at preoperative levels while sufentanil increases it. The risk of apnea was 68% lower and hypoxemia 87% lower with esketamine. However, esketamine increased the incidence of intraoperative body movement (50% vs 27%), postoperative dizziness (45% vs 30%), and nausea (7% vs 0%). No differences were found in anesthesia recovery time, sedation scores, pain, or vomiting. Esketamine provides better hemodynamic and respiratory stability but raises the risk of dizziness and nausea.