Acute DOB and PMA Administration Impairs Motor and Sensorimotor Responses in Mice and Causes Hallucinogenic Effects in Adult Zebrafish
Brain Sciences August 25, 2020 Micaela Tirri, Luisa Ponzoni, Sabrine Bilel et al. 9 citations
Two new psychoactive substances, DOB and PMA, which are structurally similar to MDMA and sold as ecstasy, impair motor behavior and sensorimotor responses in mice and induce hallucinatory states in zebrafish. In CD-1 male mice, acute administration of DOB and PMA (0.01–30 mg/kg) reduced spontaneous locomotion and disrupted prepulse inhibition of startle responses to visual, acoustic, and tactile stimuli. In zebrafish, lower doses of DOB (0.075–2 mg/kg) and PMA (0.0005–0.5 mg/kg) decreased swimming activity and reduced a hallucinatory score, indicating pro-psychedelic effects. These findings suggest the substances alter sensorimotor gating and may produce hallucinogen-like states.